PIPER-FlexPepDock is a fragment-based protocol for high-resolution global peptide-protein docking.

Starting from a given receptor structure and a peptide sequence, it streamlines the Rosetta fragment picker for accurate peptide fragment ensemble generation, the PIPER docking algorithm for exhaustive fragment-receptor rigid-body docking, and Rosetta FlexPepDock for flexible full-atom refinement of PIPER docked models, to generate highly accurate structural models of a peptide-protein interaction.

For detailed description please visit the Overview section.