PIPER-FlexPepDock is a fragment-based protocol for high-resolution global peptide-protein docking.

Starting from a given receptor structure and a peptide sequence, it streamlines the Rosetta fragment picker for accurate peptide fragment ensemble generation, the PIPER docking algorithm for exhaustive fragment-receptor rigid-body docking, and Rosetta FlexPepDock for flexible full-atom refinement of PIPER docked models, to generate highly accurate structural models of a peptide-protein interaction.

For detailed description please visit the Overview section.

Submit a job

Max receptor length is 500 residues
Peptide length range is 4-15 residues
Where results will be mailed to
Additional Options
Receptor flexibility provides better results for the cases where the receptor undergo significant structural rearragments during peptide binding but the job takes longer to finish
A sequence of H(for helix), E(extended) or C(coiled) and the same length as the peptide
Your given name of the complex
Private jobs will not appear in the Job Queue

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E-mail addresses submitted to FlexPepDock's web server are only used for tracking user's usage and returning analysis results. We may also contact you via email should any problem arise with you submission. Be sure that email addresses are not used for any other purpose and are not passed to third parties.

Intellectual Property Disclaimer

All data submitted to FlexPepDock's web server and it's analysis results is publicly accessible, hence we cannot guarantee confidentiality.